Serum amyloid A1 mediates myotube atrophy via Toll-like receptors.

Alexander HahnMelanie KnyCristina Pablo-TortolaMihail TodirasMichael WillenbrockSibylle SchmidtKatrin SchmoeckelIlka JordeMarcel NowakErnst JaroschThomas SommerBarbara M BrökerStephan B FelixClaus ScheidereitSteffen Weber-CarstensChristian ButterFriedrich C LuftJens Fielitz

Published in: Journal of cachexia, sarcopenia and muscle (2019)

SAA1 activates the TLR2/TLR4//NF-κB p65 signalling pathway to cause myocyte atrophy. Systemic inhibition of the NF-κB pathway reduced muscle atrophy and increased survival of septic mice. The SAA1/TLR2/TLR4//NF-κB p65 atrophy pathway could have utility in combatting ICUAW.

Keyphrases

toll like receptor
nuclear factor
inflammatory response
lps induced
signaling pathway
immune response
pi k akt
oxidative stress
acute kidney injury
skeletal muscle
adipose tissue
cell proliferation