Ischemic Stroke Thrombus Perviousness Is Associated with Distinguishable Proteomic Features and Susceptibility to ADAMTS13-Augmented Thrombolysis.

Derrek Schartz Sajal Medha K Akkipeddi Redi Rahmani Nathaniel R Ellens Clifton Houk Gurkirat Singh KohliLogan WorleyKevin Welle Tarun Bhalla Thomas K MattinglyCraig MorrellMatthew T Bender

Published in: AJNR. American journal of neuroradiology (2023)

Thrombus perviousness is associated with complex proteomic features, including differential abundance of platelet-related proteins in highly permeable clots with monocyte/macrophage depletion. This association may help to explain why highly pervious thrombi were also found more susceptible to ADAMTS13-augmented thrombolysis.

Keyphrases

pulmonary embolism
acute ischemic stroke
label free
dendritic cells
atrial fibrillation
virtual reality
endothelial cells