Liquid biopsy using the supernatant of a pleural effusion for EGFR genotyping in pulmonary adenocarcinoma patients: a comparison between cell-free DNA and extracellular vesicle-derived DNA.
Jong Sik LeeJae Young HurIn Ae KimHee Joung KimChang Min ChoiJae Chol LeeWan Seop KimKye Young LeePublished in: BMC cancer (2018)
Liquid biopsy using the supernatant of pleural effusions showed significantly improved results for EGFR genotyping compared to those using conventional cell block or cytology samples. Liquid biopsy using EV-derived DNA is promising for EGFR genotyping, including T790 M detection in pulmonary adenocarcinoma patients who develop pleural effusions.
Keyphrases
- fine needle aspiration
- cell free
- small cell lung cancer
- epidermal growth factor receptor
- ultrasound guided
- tyrosine kinase
- high throughput
- genome wide
- end stage renal disease
- pulmonary hypertension
- circulating tumor
- squamous cell carcinoma
- ionic liquid
- ejection fraction
- chronic kidney disease
- single molecule
- single cell
- locally advanced
- peritoneal dialysis
- prognostic factors
- high grade
- patient reported outcomes
- dna methylation
- stem cells
- loop mediated isothermal amplification
- bone marrow