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Concise Total Synthesis of Herqulines B and C.

Chi HeThomas P StrattonPhil S Baran
Published in: Journal of the American Chemical Society (2018)
A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive reductions. Emerging from these studies are strategic insights on the synthesis of these strained alkaloids, as well as mild conditions for the exhaustive reduction of diketopiperizines.
Keyphrases
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