Advancing ethanol content determination in hydrogels: non-destructive and operational methods for health and criminal inspections.
Diego M de SouzaLívia de B SalumRobiedson R DamascenoPedro J de Moura MessiasCamila M SilvaJoão V de S CardosoPedro A de Oliveira MoraisPublished in: Analytical sciences : the international journal of the Japan Society for Analytical Chemistry (2024)
The significance of accurate determination of ethanol content in hydrogel formulations was accentuated during COVID-19 pandemic coinciding with the heightened demand for sanitizing agents. The present article proposes three robust methodologies for this purpose: Fourier Transform Infrared Spectroscopy (FTIR), Raman spectroscopy, and Densitometry with matrix effect correction by Near-Infrared Spectroscopy (NIR). All three methods demonstrated outstanding linearity (R 2 ≥ 0.99) and minimal errors (< 1.7%), offering simplicity and operational efficiency. FTIR and Raman, being non-destructive and requiring minimal preparation, enable practical on-site analysis capabilities, underscoring the potential of the spectroscopic methods to expedite health investigations and inspections, empowering on-site ethanol determination, and relieving the burden on official laboratories. Additionally, the densitometry with NIR-based approach showcased superior accuracy and precision compared to spectroscopic methods, meeting validation criteria while offering operational advantages over the costly official distillation-based method. Therefore, it stands as a reliable and reproducible technique for comprehensive health and criminal compliance assessments, making it a compelling alternative for both industry and official laboratories.
Keyphrases
- raman spectroscopy
- healthcare
- public health
- molecularly imprinted
- mental health
- solid phase extraction
- molecular docking
- health information
- drug delivery
- drug release
- human health
- health promotion
- high resolution
- hyaluronic acid
- emergency department
- fluorescent probe
- fluorescence imaging
- extracellular matrix
- mass spectrometry
- molecular dynamics simulations
- quality improvement
- electronic health record