Clinical correlates of R1 relaxometry and magnetic susceptibility changes in multiple sclerosis: a multi-parameter quantitative MRI study of brain iron and myelin.
Giuseppe PontilloMaria PetraccaSerena MontiMario QuarantelliRoberta LanzilloTeresa CostabileAntonio CarotenutoFabio TortoraAndrea ElefanteVincenzo Brescia MorraArturo BrunettiGiuseppe PalmaSirio CocozzaPublished in: European radiology (2022)
• Compared to healthy controls, multiple sclerosis patients showed R1 and χ changes suggestive of iron increase within the basal ganglia and reduced iron and myelin content within (subnuclei of) the thalamus. • Thalamic volume and χ changes significantly predicted clinical disability, as well as pulvinar R1 and χ changes, independently from atrophy. • Atrophy-independent R1 and χ changes, suggestive of thalamic iron and myelin depletion, may represent a sensitive marker of subclinical inflammation.
Keyphrases
- multiple sclerosis
- white matter
- deep brain stimulation
- iron deficiency
- end stage renal disease
- chronic kidney disease
- ejection fraction
- newly diagnosed
- oxidative stress
- magnetic resonance imaging
- prognostic factors
- peritoneal dialysis
- high resolution
- contrast enhanced
- patient reported outcomes
- magnetic resonance
- brain injury
- patient reported