Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma.

Zhitao JiangLiyuan GaoChundi LiuJianchun WangYi HanJinhuo Pan

Published in: Journal of clinical and translational hepatology (2023)

This study showed sarmentosin stimulated autophagic and caspase-dependent apoptosis in HCC, which required activation of Nrf2 and inhibition of mTOR. Our research supports Nrf2 as a therapeutic target for HCC and sarmentosin as a promising candidate for HCC chemotherapy.

Keyphrases

oxidative stress
cell death
cell cycle arrest
endoplasmic reticulum stress
induced apoptosis
cell proliferation
signaling pathway
locally advanced
squamous cell carcinoma
chemotherapy induced