Therapeutic application of nicotinamide: As a potential target for inhibiting fibrotic scar formation following spinal cord injury.

Ce ZhangQiang ShaoYing ZhangWenjing LiuJianning KangZhengxin JinNana HuangBin Ning

Published in: CNS neuroscience & therapeutics (2024)

Our functional metabolomics strategy identified nicotinamide as a metabolite with the potential to inhibit fibrotic scar formation following SCI by suppressing the TGFβ/SMADs signaling. This finding provides new therapeutic strategies and new ideas for clinical treatment.

Keyphrases

spinal cord injury
systemic sclerosis
transforming growth factor
idiopathic pulmonary fibrosis
spinal cord
mass spectrometry
signaling pathway
neuropathic pain
combination therapy
risk assessment