Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness.

Chaoyi ChenHongfei YuFengyan HanXuan LaiKehong YeSiqin LeiMinglang MaiMaode LaiHonghe Zhang

Published in: Molecular cancer (2022)

circRHOBTB3 plays a tumor-suppressive role in CRC and has to be excreted out of cells to sustain cancer cell fitness. ASOs targeting regulatory elements for circularization and exosomal secretion will become a novel antitumor strategy.

Keyphrases

induced apoptosis
cell cycle arrest
physical activity
body composition
endoplasmic reticulum stress
transcription factor
oxidative stress
cancer therapy
cell proliferation
pi k akt