Relationship between Insulin Resistance (HOMA-IR), Trabecular Bone Score (TBS), and Three-Dimensional Dual-Energy X-ray Absorptiometry (3D-DXA) in Non-Diabetic Postmenopausal Women.
Francisco Campillo-SánchezRicardo Usategui-MartinÁngela Ruiz-de TemiñoJudith GilMarta Ruiz-MambrillaJose María Fernández-GómezAntonio Dueñas-LaitaJosé Luis Pérez-CastrillónPublished in: Journal of clinical medicine (2020)
In non-diabetic postmenopausal women there was a direct relationship between insulin resistance and vBMD, whose effect is directly related to greater weight. TBS had an inverse relationship with HbA1c, insulin, and insulin resistance unrelated to weight. This might be explained by the formation of advanced glycosylation products (AGEs) in the bone matrix, which reduces bone deformation capacity and resistance, as well as increases fragility.
Keyphrases
- bone mineral density
- postmenopausal women
- insulin resistance
- dual energy
- type diabetes
- computed tomography
- adipose tissue
- high fat diet
- polycystic ovary syndrome
- metabolic syndrome
- skeletal muscle
- body composition
- body mass index
- high fat diet induced
- glycemic control
- weight loss
- physical activity
- weight gain
- high resolution
- wound healing
- image quality
- body weight
- magnetic resonance imaging
- mass spectrometry
- magnetic resonance
- electron microscopy