Recent Advances of Oxalate Decarboxylase: Biochemical Characteristics, Catalysis Mechanisms, and Gene Expression and Regulation.
XinYi ZanYing YanGege ChenLei SunLinhan WangYixin WenYuting XuZiying ZhangXinlin LiYumeng YangWenjing SunFeng-Jie CuiPublished in: Journal of agricultural and food chemistry (2024)
Oxalate decarboxylase (OXDC) is a typical Mn 2+ /Mn 3+ dependent metal enzyme and splits oxalate to formate and CO 2 without any organic cofactors. Fungi and bacteria are the main organisms expressing the OXDC gene, but with a significantly different mechanism of gene expression and regulation. Many articles reported its potential applications in the clinical treatment of hyperoxaluria, low-oxalate food processing, degradation of oxalate salt deposits, oxalate acid diagnostics, biocontrol, biodemulsifier, and electrochemical oxidation. However, some questions still remain to be clarified about the role of substrate binding and/or protein environment in modulating the redox properties of enzyme-bound Mn(II)/Mn(III), the nature of dioxygen involved in the catalytic mechanism, and how OXDC acquires Mn(II) /Mn(III). This review mainly summarizes its biochemical and structure characteristics, gene expression and regulation, and catalysis mechanism. We also deep-mined oxalate decarboxylase gene data from National Center for Biotechnology Information to give some insights to explore new OXDC with diverse biochemical properties.
Keyphrases
- gene expression
- room temperature
- dna methylation
- transition metal
- metal organic framework
- genome wide
- gold nanoparticles
- copy number
- healthcare
- signaling pathway
- risk assessment
- binding protein
- ionic liquid
- quality improvement
- deep learning
- high resolution
- human health
- big data
- transcription factor
- amino acid
- smoking cessation
- health information
- dna binding
- mass spectrometry
- crystal structure