WNT4 Regulates Cellular Metabolism via Intracellular Activity at the Mitochondria in Breast and Gynecologic Cancers.

Joseph L Sottnik Madeleine T Shackleford Sydney K Robinson Fabian R Villagomez Shaymaa Bahnassy Steffi Oesterreich Junxiao Hu Zeynep Madak Erdogan Rebecca B Riggins Bradley R Corr Linda S Cook Lindsey S Treviño Benjamin G Bitler Matthew J Sikora

Published in: Cancer research communications (2024)

WNT4 regulates breast and gynecologic cancer metabolism via a previously unappreciated intracellular signaling mechanism at the mitochondria, with WNT4 mediating metabolic remodeling. Understanding WNT4 dysregulation by estrogen and genetic polymorphism offers new opportunities for defining tumor biology, precision therapeutics, and personalized cancer risk assessment.

Keyphrases

cell proliferation
stem cells
papillary thyroid
reactive oxygen species
risk assessment
squamous cell
cell death
childhood cancer
small molecule
estrogen receptor
young adults
dna methylation
copy number