WMJ-8-B, a novel hydroxamate derivative, induces MDA-MB-231 breast cancer cell death via the SHP-1-STAT3-survivin cascade.

Yu-Fan ChuangShiu-Wen HuangYa-Fen HsuMeng-Chieh YuGeorge OuWei-Jan HuangMing-Jen Hsu

Published in: British journal of pharmacology (2017)

The SHP-1-STAT3-survivin and Sp1-p21 cascades are involved in WMJ-8-B-induced MDA-MB-231 breast cancer cell death. These results also indicate the potential of WMJ-8-B as a lead compound for treatment of breast cancer and warrant its clinical development.

Keyphrases

cell death
cell cycle arrest
cell proliferation
breast cancer cells
high glucose
oxidative stress
drug induced
endothelial cells
signaling pathway