Mesenchymal stem cell-derived exosomal miR-146a reverses diabetic β-cell dedifferentiation.

Qin HeJia SongChen CuiJinbang WangHuiqing HuXinghong GuoMengmeng YangLingshu WangFei YanKai LiangZhaojian LiuFuqiang LiuZheng SunMing DongXinguo HouLi Chen

Published in: Stem cell research & therapy (2021)

These findings demonstrate that bmMSC-derived exosomal miR-146a protects against diabetic β-cell dysfunction by acting on the NUMB/β-catenin signaling pathway, which may represent a novel therapeutic strategy for T2DM.

Keyphrases

cell proliferation
long non coding rna
single cell
cell therapy
type diabetes
long noncoding rna
wound healing
oxidative stress
metabolic syndrome
skeletal muscle