Thrombin in complex with dabigatran can still interact with PAR-1 via exosite-I and instigate loss of vascular integrity.
Sophie C DóllemanStijn M AgtenHenri M H SpronkTilman M HackengMettine H A BosHenri H VersteegAnton Jan van ZonneveldHetty C de BoerPublished in: Journal of thrombosis and haemostasis : JTH (2022)
Proteolytically inactive thrombin in complex with dabigatran evokes loss of barrier function that can be prevented by a protease-activated receptor-1 mimicking peptide blocking thrombin's exosite-I.
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