Genetic and pharmacological inhibition of two-pore domain potassium channel TREK-1 alters depression-related behaviors and neuronal plasticity in the hippocampus in mice.

Fangfang WuHongbin SunWeigang GongXiaoli LiZhaohui PanHan ShanZhi-Jun Zhang

Published in: CNS neuroscience & therapeutics (2020)

Our results indicate a role for TREK-1 in the modulation of synaptic plasticity in a mouse model of depression. These findings will provide insight into the pathological mechanism of depression and further evidence for a novel target for antidepressant treatment.

Keyphrases

depressive symptoms
mouse model
sleep quality
genome wide
cerebral ischemia
adipose tissue
physical activity
copy number
gene expression
brain injury
combination therapy
smoking cessation