OTULIN couples WNT signaling to resistance in triple-negative breast cancer.

Published in: Molecular & cellular oncology (2020)

Oncogenic Wnt/β-catenin activation promotes cancer development and drug resistance to cancer treatments. We recently revealed an underlying mechanism linking linear ubiquitination with Wnt/β-catenin activation upon genotoxic treatments. We showed that ABL1 (ABL proto-oncogene 1)-dependent phosphorylation of OTULIN (OTU deubiquitinase with linear linkage specificity) upon DNA damage drives β-catenin activation which promotes drug resistance in triple-negative breast cancer.

Keyphrases

cell proliferation
dna damage
papillary thyroid
epithelial mesenchymal transition
squamous cell
stem cells
tyrosine kinase
oxidative stress
childhood cancer
genome wide
dna repair
single cell
young adults
signaling pathway
protein kinase
men who have sex with men
hiv testing