Lentiviral overexpression of VEGFC in transplanted MSCs leads to resolution of swelling in a mouse tail lymphedema model.
Eleftheria MichalakiJosephine M RuddLauren LiebmanRahul WadhwaniLevi B WoodNick J WillettJ Brandon DixonPublished in: Microcirculation (New York, N.Y. : 1994) (2022)
Our results suggest a therapeutic potential of hVEGFC MSC in alleviating the lymphatic dysfunction observed during lymphedema progression after secondary injury and could provide a promising approach to enhancing autologous cell therapy for treating lymphedema.