Mitochondria and Doxorubicin-Induced Cardiomyopathy: A Complex Interplay.
Leonardo SchironeLuca D'AmbrosioMaurizio ForteRiccardo GenoveseSonia SchiavonGiulia SpinosaGiuliano IacovoneValentina ValentiGiacomo FratiSebastiano SciarrettaPublished in: Cells (2022)
Cardiotoxicity has emerged as a major side effect of doxorubicin (DOX) treatment, affecting nearly 30% of patients within 5 years after chemotherapy. Heart failure is the first non-cancer cause of death in DOX-treated patients. Although many different molecular mechanisms explaining the cardiac derangements induced by DOX were identified in past decades, the translation to clinical practice has remained elusive to date. This review examines the current understanding of DOX-induced cardiomyopathy (DCM) with a focus on mitochondria, which were increasingly proven to be crucial determinants of DOX-induced cytotoxicity. We discuss DCM pathophysiology and epidemiology and DOX-induced detrimental effects on mitochondrial function, dynamics, biogenesis, and autophagy. Lastly, we review the current perspectives to contrast the development of DCM, which is still a relatively diffused, invalidating, and life-threatening condition for cancer survivors.
Keyphrases
- heart failure
- end stage renal disease
- high glucose
- diabetic rats
- newly diagnosed
- ejection fraction
- chronic kidney disease
- cell death
- clinical practice
- drug induced
- magnetic resonance
- drug delivery
- oxidative stress
- prognostic factors
- squamous cell carcinoma
- young adults
- peritoneal dialysis
- magnetic resonance imaging
- endothelial cells
- radiation therapy
- atrial fibrillation
- patient reported outcomes
- papillary thyroid
- cancer therapy
- endoplasmic reticulum stress
- contrast enhanced
- replacement therapy