Identification of isoaspartate-modified transthyretin as potential target for selective immunotherapy of transthyretin amyloidosis.

Janett KöppenMartin KleinschmidtMarkus MorawskiJens-Ulrich RahfeldMichael WermannHolger CynisUte HegenbartChristoph DanielSteffen RoßnerStephan SchillingAnja Schulze

Published in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis (2024)

These antibodies label aged, non-native TTR deposits, leaving native TTR unattended and thereby potentially enabling new therapeutic approaches.

Keyphrases

wild type
multiple myeloma
human health