Sex-Related Signaling of Aldosterone/Mineralocorticoid Receptor Pathway in Calcific Aortic Stenosis.
Lara MatillaEva JoverMattie GaraikoetxeaErnesto Martín-NuñezVanessa ArrietaAmaia García-PeñaAdela NavarroAmaya Fernández-CelisAlicia GainzaVirginia ÁlvarezDiego Alvarez de la RosaRafael SadabaFrédéric JaisserNatalia Lopez-AndreésPublished in: Hypertension (Dallas, Tex. : 1979) (2022)
These findings demonstrate that the Aldo/MR pathway could play a role in early stages of aortic stenosis by promoting VICs activation, fibrosis, and ulterior calcification. Importantly, Aldo/MR pathway is involved in fibrosis in women and in early AV calcification only in men. Accordingly, MR antagonism emerges as a new sex-specific pharmacological treatment to prevent AV alterations.
Keyphrases
- aortic stenosis
- transcatheter aortic valve replacement
- ejection fraction
- aortic valve replacement
- aortic valve
- transcatheter aortic valve implantation
- left ventricular
- contrast enhanced
- coronary artery disease
- magnetic resonance
- chronic kidney disease
- type diabetes
- magnetic resonance imaging
- polycystic ovary syndrome
- heart failure
- angiotensin ii
- middle aged
- pregnant women
- atrial fibrillation