Increased Synaptic Strength and mGlu2/3 Receptor Plasticity on Mouse Prefrontal Cortex Intratelencephalic Pyramidal Cells Following Intermittent Access to Ethanol.

Max E Joffe Danny G WinderP Jeffrey Conn

Published in: Alcoholism, clinical and experimental research (2021)

Together, these studies provide insight into the specific PFC neurocircuits altered by voluntary drinking. In addition, the findings provide an additional rationale for developing compounds that potentiate mGlu2 and/or mGlu3 receptor function as potential treatments for AUD.

Keyphrases

prefrontal cortex
induced apoptosis
cell cycle arrest
clinical trial
high intensity
binding protein
oxidative stress
signaling pathway
cell death