Molecular mechanisms by which HERV-K Gag interferes with HIV-1 Gag assembly and particle infectivity.
Kazuaki MondeHiromi TerasawaYusuke NakanoFerri SoheilianKunio NagashimaYosuke MaedaAkira OnoPublished in: Retrovirology (2017)
Our results showed that HERV-K Gag CA is important for reduction of HIV-1 release and infectivity but the different regions within CA are involved in the effects on the HIV-1 release and infectivity. Altogether, these findings revealed that HERV-K Gag interferes the HIV-1 replication by two distinct molecular mechanisms.