Tumor-released autophagosomes induces CD4+ T cell-mediated immunosuppression via a TLR2-IL-6 cascade.
Yong-Qiang ChenPeng-Cheng LiNing PanRong GaoZhi-Fa WenTian-Yu ZhangFang HuangFang-Yuan WuXi-Long OuJin-Ping ZhangXue-Jun ZhuHong-Ming HuKang ChenYun-Lang CaiLi-Xin WangPublished in: Journal for immunotherapy of cancer (2019)
HSP90α on the surface of TRAPs programs the immunosuppressive functions of CD4+ T cells to promote tumor growth and metastasis. TRAPs or their membrane-bound HSP90α represent important therapeutic targets to reverse cancer-associated immunosuppression and improve immunotherapy.