Circulating Biomarkers in Hypertrophic Cardiomyopathy.

Eldon L MatthiaMichael L SetteducatoMohammed ElzeneiniNicholas VernaceMichael SalernoChristopher M Kramer Ellen C Keeley

Published in: Journal of the American Heart Association (2022)

Hypertrophic cardiomyopathy is the most common genetic heart disease. Biomarkers, molecules measurable in the blood, could inform the clinician by aiding in diagnosis, directing treatment, and predicting outcomes. We present an updated review of circulating biomarkers in hypertrophic cardiomyopathy representing key pathologic processes including wall stretch, myocardial necrosis, fibrosis, inflammation, hypertrophy, and endothelial dysfunction, in addition to their clinical significance.

Keyphrases

hypertrophic cardiomyopathy
left ventricular
oxidative stress
neoadjuvant chemotherapy
pulmonary hypertension
squamous cell carcinoma
gene expression
copy number
metabolic syndrome
liver fibrosis