Investigating the T Regulatory Cells and Sirtuin -I Serum Level in Immunotherapy Treated House Dust Mite Allergic Asthma Patients.
Rania A MohamedAhmed ElSadek FakhrShereen A BaioumyPublished in: The Journal of asthma : official journal of the Association for the Care of Asthma (2023)
This study revealed that both CD4 CD25 and CD4 CD25 high FOXP3 cell percentages increased in the WIT group and declined in the WOIT group. While, FOXP3 gene expression increased in both groups. In addition, the Sirt1 serum level showed some improvement in WIT group after a serious drop in the WOIT group comparing with the CT group. The modulation of these biomarkers for the remission and control of allergic asthma can be a prognostic outcome of immunotherapy which needs to be confirmed by larger scale studies.
Keyphrases
- gene expression
- allergic rhinitis
- chronic obstructive pulmonary disease
- newly diagnosed
- regulatory t cells
- single cell
- computed tomography
- induced apoptosis
- lung function
- oxidative stress
- magnetic resonance imaging
- stem cells
- cell proliferation
- cell death
- risk assessment
- cystic fibrosis
- cell cycle arrest
- mesenchymal stem cells
- dual energy
- image quality
- patient reported
- disease activity
- atopic dermatitis
- polycyclic aromatic hydrocarbons
- pi k akt
- peritoneal dialysis