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Occult and active hepatitis B virus detection in donated blood in São Paulo, Brazil.

Anna Shoko NishiyaJosé Eduardo LeviCesar de Almeida NetoSteven Sol WitkinSuzete Cleusa FerreiraLeda C BassitEster Cerdeira SabinoClaudia Di Lorenzo OliveiraNanci A SallesAdenilson S CoutinhoMaria A BellesaVanderson Geraldo RochaAlfredo Mendrone
Published in: Transfusion (2021)
Highly sensitive molecular tests improve the capacity to detect OBIs. When NAT is performed in pooled samples, HBcAb test has value in the detection of donors with OBI and improves transfusion safety. Mutations in the S gene are frequent in HBsAg-positive blood, including those associated with diagnostic failure and vaccine escape mutations.
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