Nucleotides Cytidine and Uridine Associated with Vitamin B12 vs B-Complex Vitamins in the Treatment of Low Back Pain: The NUBES Study.
Marco Antonio Naslausky MibielliCarlos Pereira NunesHenrique GoldbergLuiz BuchmanLisa OliveiraSpyros G E MezitisFernanda WajnzstajnRenato KaufmanRafael NigriNatasha CytrynbaumKarin Soares CunhaAlessandra SantosStephanie Wrobel GoldbergNatália Carvalho PlatenikHelio RzetelnaDaniel Bertoluci FuturoAdenilson de Souza Da FonsecaMauro GellerPublished in: Journal of pain research (2020)
Treatment with nucleotides+B12 was associated with a lower number of total AEs, fewer AEs per subject, and no AE-related treatment discontinuation. Pain intensity (VAS) reduction was superior at 30 days of treatment in the nucleotides+B12 group and equivalent between groups at 60 days of treatment. Improvements in efficacy measures RMQ and FFD were observed in both groups at treatment days 30 and 60.