Characterization of Serotonin Signaling Components in Patients with Inflammatory Bowel Disease.
Md Sharif ShajibUsha ChauhanSalman AdeebYeshale ChettyDavid ArmstrongSmita L S HalderJohn K MarshallWaliul I KhanPublished in: Journal of the Canadian Association of Gastroenterology (2018)
Our results suggest that augmented mucosal 5-HT signaling and specific 5-HTTLPR genotype-associated decreased efficiency in 5-HT reuptake, the latter through increased 5-HT availability, may contribute to inflammation in CD patients. These findings revealed important information on various components of 5-HT signaling in intestinal inflammation which may ultimately lead to effective strategies targeting this pathway in IBD.