Population pharmacokinetic modelling of intravenous paracetamol in fit older people displays extensive unexplained variability.
Paola MianM J van EsdonkK T OlkkolaB C M de WinterA LiukasI SprietD TibboelM PetrovicB C P KochKarel AllegaertPublished in: British journal of clinical pharmacology (2018)
The target concentration was achieved in the average patient with 1000 mg every 6 h, while every 8 h resulted in underdosing for the majority of the population. Furthermore, due to a large (unexplained) interindividual variability in paracetamol PK a relevant proportion of the fit older people remained either under- or over exposed.