Med1 inhibits ferroptosis and alleviates liver injury in acute liver failure via Nrf2 activation.

Zi-Ying LeiZhi-Hui LiDeng-Na LinJing CaoJun-Feng ChenShi-Bo MengJia-Lei WangJing LiuJing ZhangBing-Liang Lin

Published in: Cell & bioscience (2024)

Overall, our research findings indicate that Med1 suppresses ferroptosis and alleviates liver injury in LPS/D-GalN-induced ALF through the activation of Nrf2. These findings substantiate the therapeutic viability of targeting the Med1-Nrf2 axis as a means of treating individuals afflicted with ALF.

Keyphrases

liver injury
drug induced
liver failure
oxidative stress
cell death
hepatitis b virus
diabetic rats
inflammatory response
mouse model
cancer therapy
intensive care unit