Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.

Kumait Al LawatiSameer SharifSaid Al MaqbaliHussein Al RimawiAndrew PetrosoniakEmilie P Belley-CoteSunjay V SharmaJustin MorgensternShannon M FernandoJulian J OwenMichelle ZellerDavid QuinlanWaleed AlhazzaniBram Rochwerg

Published in: Intensive care medicine (2020)

In patients with acute TBI, TXA probably has no effect on mortality or disability. TXA may decrease hematoma expansion on subsequent imaging; however, this outcome is likely of less importance to patients. The use of TXA probably does not increase the risk of adverse events.

Keyphrases

traumatic brain injury
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
high resolution
multiple sclerosis
liver failure
prognostic factors
type diabetes
intensive care unit
mass spectrometry
aortic dissection
acute respiratory distress syndrome