YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer.
Fan LiYan XuBovey LiuPankaj Kumar SinghWei ZhaoJiankang JinGuangchun HanAiling W ScottXiaochuan DongLongfei HuoLang MaMelissa Pool PizziYing WangYuan LiKazuto HaradaMin XieHeath D SkinnerSheng DingLinghua WangSunil KrishnanRandy L JohnsonShumei SongJaffer A AjaniPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)
Our results document that a positive crosstalk between the YAP1 and CDK6 pathways plays an important role in conferring radiation resistance to esophageal cancer cells. Targeting both YAP1 and CDK6 pathways could be a novel therapeutic strategy to overcome resistance in esophageal cancer.
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