Utility of Diabetes Type-Specific Genetic Risk Scores for the Classification of Diabetes Type Among Multiethnic Youth.

Richard D OramSeth A SharpCatherine PihokerLauric FerratGiuseppina ImperatoreAdrienne WilliamsMaria J RedondoLynne WagenknechtLawrence M DolanJean M LawrenceMichael N WeedonRalph D'AgostinoWilliam A HagopianJasmin DiversDana Dabelea

Published in: Diabetes care (2022)

Diabetes type-specific GRS are consistent predictors of diabetes type across racial/ethnic groups in a U.S. youth cohort, but future work needs to account for differences in GRS distribution by ancestry. T1D and T2D GRS may have particular utility for classification of DAA- children.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
young adults
machine learning
deep learning
mental health
physical activity
gene expression
dna methylation
genome wide
insulin resistance
current status
copy number