Patterns of subregional cerebellar atrophy across epilepsy syndromes: An ENIGMA-Epilepsy study.
Rebecca KerestesAndrew PerryLucy E VivashTerence J O'BrienMarina K M AlvimDonatello ArienzoÍtalo K AventuratoAlice BalleriniGabriel F BaltazarNúria BargallóBenjamin BenderRicardo BrioschiEva BürkleMaria Eugenia CaligiuriFernando CendesJane de TisiJohn S DuncanJerome P EngelSonya FoleyFrancesco FortunatoAntonio GambardellaThea GiacominiRenzo GuerriniGerard R HallKhalid HamandiVictoria Ives-DeliperiRafael B JoãoSimon S KellerBenedict KleiserAngelo LabateMatteo LengeCassandra MarottaPascal MartinMario MascalchiStefano MelettiConor Owens-WaltonCostanza B ParodiSaül Pascual-DiazDavid PowellJun RaoMichael RebsamenJohannes T ReiterAntonella RivaTheodor RuberChristian RummelFreda SchefflerMariasavina SeverinoLucas S SilvaRichard J StabaDan J SteinPasquale StrianoPeter Neal TaylorSophia I ThomopoulosPaul M ThompsonDomenico TortoraAnna Elisabetta VaudanoBernd WeberRoland WiestGavin P WinstonClarissa L YasudaHong ZhengCarrie R McDonaldSanjay M SisodiyaIan H HardingPublished in: Epilepsia (2024)
We provide robust evidence of deep cerebellar and posterior lobe subregional gray matter volume loss in patients with chronic epilepsy. Volume loss was maximal for posterior subregions implicated in nonmotor functions, relative to motor regions of both the anterior and posterior lobe. Associations between cerebral and cerebellar changes, and variability of neuroanatomical profiles across epilepsy syndromes argue for more precise incorporation of cerebellar subregional damage into neurobiological models of epilepsy.