Interleukin-6 induces VEGF secretion from prostate cancer cells in a manner independent of androgen receptor activation.

Kenichiro IshiiTakeshi SasakiKazuhiro IguchiShinya KajiwaraManabu KatoHideki KandaYoshifumi HirokawaKiminobu ArimaAtsushi MizokamiYoshiki Sugimura

Published in: The Prostate (2018)

Our results suggest that IL-6 might induce VEGF secretion from PCa cells in a manner independent of AR activation. To prevent IL-6-induced VEGF secretion, inhibition of the PI3K/AKT signaling pathway could be an important pharmacological goal regardless of ADT.

Keyphrases

vascular endothelial growth factor
endothelial cells
induced apoptosis
signaling pathway
high glucose
endoplasmic reticulum stress
diabetic rats
pi k akt
oxidative stress
epithelial mesenchymal transition
drug induced