Circadian Variations in Sympathetic Vasoconstriction in Older Adults with and Without Type 2 Diabetes.

Alessandro GentilinPaolo MoghettiAntonio CeveseAnna Vittoria MattioliFederico SchenaCantor Tarperi

Published in: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension (2023)

Peripheral vasoconstriction triggered by a standardized sympathetic stressor is similar between morning and evening, regardless of T2DM and different baseline VC values. However, peripheral vasoconstriction responsiveness is blunted in individuals with T2DM as handgrip-mediated sympathoexcitation induces vasodilation in the contralateral forearm in adults with T2DM and vasoconstriction in healthy age-matched controls, highlighting a neurovascular response altered by T2DM.

Keyphrases

glycemic control
type diabetes
cardiovascular disease
insulin resistance
adipose tissue
community dwelling