Uptake and tumor-suppressive pathways of exosome-associated GKN1 protein in gastric epithelial cells.

Jung Hwan YoonHassan AshktorabDuane T SmootSuk Woo NamHoon HurWon Sang Park

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2020)

Gastric-specific uptake of exosomes derived from gastric epithelial cells requires integrin α6 and αX proteins in both gastric epithelial cells and exosomes. Exosomal GKN1 protein inhibits gastric carcinogenesis by downregulating HRas/Raf/MEK/ERK signaling pathways.

Keyphrases

signaling pathway
stem cells
pi k akt
protein protein
oxidative stress
amino acid
small molecule
bone marrow
cell adhesion