Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study.
P RavanfarWarda T SyedaNikos MakrisBradford A MoffatAmanda E LyallA H MerrittGabriel Allan DevenyiM Mallar ChakravartyPatricia M DesmondVanessa L CropleyNikos MakrisMartha E ShentonAshley I BushDennis VelakoulisChristos PantelisMark WalterfangPublished in: AJNR. American journal of neuroradiology (2023)
Our findings suggest iron deposition in the pulvinar nucleus in Niemann-Pick type C disease, which is associated with thalamic atrophy and disease severity. This preliminary evidence supports the link between iron and neurodegeneration in Niemann-Pick type C, in line with existing literature on other neurodegenerative disorders.