Investigation of Brain Iron in Niemann-Pick Type C: A 7T Quantitative Susceptibility Mapping Study.

P Ravanfar Warda T Syeda Nikos Makris Bradford A Moffat Amanda E Lyall A H Merritt Gabriel Allan Devenyi M Mallar Chakravarty Patricia M Desmond Vanessa L Cropley Nikos Makris Martha E Shenton Ashley I Bush Dennis Velakoulis Christos Pantelis Mark Walterfang

Published in: AJNR. American journal of neuroradiology (2023)

Our findings suggest iron deposition in the pulvinar nucleus in Niemann-Pick type C disease, which is associated with thalamic atrophy and disease severity. This preliminary evidence supports the link between iron and neurodegeneration in Niemann-Pick type C, in line with existing literature on other neurodegenerative disorders.

Keyphrases

high resolution

iron deficiency

deep brain stimulation