Hematopoietic stem cell transplantation in serine/threonine kinase 4 (STK4) deficiency: Report of two cases and literature review.

Vedat UygunSevgi KeleşHayriye DaloğluSeda ÖztürkmenKoray YalÇinGülsün KarasuMehmet Akif Yesilipek

Published in: Pediatric transplantation (2022)

Serine/threonine kinase 4 deficiency is a disease with high mortality post-HSCT; therefore, the conditioning regimen and GVHD prophylaxis strategies are important considerations in these patients. In our opinion, the conditioning regimen, which includes rituximab and busulfan and fludarabine (BU-FLU), GVHD prophylaxis with sirolimus and MMF, and short-term methotrexate, offers favorable outcomes and is well tolerated in our STK4-deficient patients.

Keyphrases

protein kinase
end stage renal disease
newly diagnosed
ejection fraction
prognostic factors
diffuse large b cell lymphoma
acute myeloid leukemia
low dose
high dose
cardiovascular disease
skeletal muscle
patient reported outcomes
tyrosine kinase
case report
insulin resistance