Terpenoids and Phenylpropanoids Isolated from the Twigs and Leaves of Abelia macrotera and Their Anti-Inflammatory Activities.
Yang XuHuiru XieHongbo ChenLiangliang XiongKuiru SaXuanbin WangHua LiLi-Xia ChenPublished in: Chemistry & biodiversity (2022)
A new triterpenoid, 3β-hydroxyurs-12-en-28,20β-olide (1), as well as thirteen known terpenoids (2-14) and three known phenylpropanoids (15-17), were isolated from the twigs and leaves of Abelia macrotera. Compounds 2, 5-17 were isolated for the first time from the Abelia genus. The structure of compound 1 was determined using the characteristic spectral data (HR-ESI-MS, UV, 1D and 2D-NMR, and X-ray single-crystal diffraction. Furthermore, the inhibitory effects of all compounds on NO production in LPS-induced RAW 264.7 cells were tested, and compound 15 showed obvious inhibitory effect, with IC 50 values of 23.77±1.61 μM. Through target screening and molecular docking technology, it can be speculated that compound 15 may play an anti-inflammatory role by combining with Cathepsin G & Chymase and HPG D.
Keyphrases
- molecular docking
- anti inflammatory
- lps induced
- ms ms
- inflammatory response
- high resolution
- induced apoptosis
- molecular dynamics simulations
- cell cycle arrest
- magnetic resonance
- mass spectrometry
- multiple sclerosis
- dual energy
- solid state
- optical coherence tomography
- oxidative stress
- big data
- essential oil
- cell death
- signaling pathway
- data analysis
- pi k akt