The Population Pharmacokinetics of High-Dose Methotrexate in Infants with Acute Lymphoblastic Leukemia Highlight the Need for Bedside Individualized Dose Adjustment: A Report from the Children's Oncology Group.
Ryan J BeechinorPatrick A ThompsonMichael F HwangRyan C VargoLisa R BomgaarsJacqueline G GerhartZoAnn E DreyerDaniel GonzalezPublished in: Clinical pharmacokinetics (2020)
Infants treated with high-dose methotrexate demonstrated a relatively high degree of IOV in methotrexate CL. The magnitude of IOV in the CL of methotrexate suggests that use of a bedside algorithm may avoid supratherapeutic methotrexate concentrations resulting from high IOV in methotrexate CL.