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Autoantibodies to speckled protein family in primary biliary cholangitis.

Alessandro GranitoLuigi MuratoriFrancesco TovoliPaolo Muratori
Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2021)
The autoantibody profile of primary biliary cholangitis (PBC) includes antinuclear antibodies (ANA) which are detectable by indirect immunofluorescence in more than 50% of PBC patients. One of the two immunofluorescence patterns which are historically considered "PBC-specific" is the so-called "multiple nuclear dots" (MND) targeting nuclear body proteins such as Sp100, Sp140, Sp140L proteins, promyelocytic leukemia protein (PML) and small ubiquitin-related modifier proteins (SUMO). It has been hypothesized a role of nuclear body protein alterations in immune disorders such as PBC, thus suggesting novel and more refined therapeutic approaches.
Keyphrases
  • end stage renal disease
  • protein protein
  • ejection fraction
  • chronic kidney disease
  • binding protein
  • bone marrow
  • systemic lupus erythematosus
  • drug delivery
  • patient reported outcomes
  • high resolution