Design of a Drug-Eluting Subcutaneous Implant of the Antiretroviral Tenofovir Alafenamide Fumarate.

Solange M SimpsonLakmini WidanapathiranaJonathan T SuSamuel SungDavid WatrousJiang QiuElizabeth PearsonAlex EvanoffDipu KarunakaranJorge E ChaconPatrick F Kiser

Published in: Pharmaceutical research (2020)

The release rate of tenofovir alafenamide mechanistically varied with geometry and rate controlling membrane composition. The polyether urethane implant presented herein is modular and tunable to adjust the release rate and duration of the TAF release.

Keyphrases

antiretroviral therapy
hiv infected
soft tissue
hiv positive