Role of miR-93-5p and Its Opposing Effect of Ionizing Radiation in Non-Small Cell Lung Cancer.

Published in: Analytical cellular pathology (Amsterdam) (2024)

miR-93-5p is presumed to play an oncogenic role in lung cancer by enhancing A549 cell proliferation and migration. It can enhance the sensitivity of radiotherapy under IR conditions. We speculate that the miR-93-5p/GSDME pathway was inhibited, activating the GSDME-related pyroptosis pathway when the cells were exposed to IR. Therefore, miR-93-5p can overcome resistance to radiotherapy and improve the efficacy of radiotherapy.

Keyphrases

early stage
locally advanced
radiation therapy
radiation induced
induced apoptosis
signaling pathway
rectal cancer
squamous cell carcinoma
cell cycle arrest
cell therapy
transcription factor
oxidative stress
stem cells
nlrp inflammasome
mesenchymal stem cells
cell death
cell proliferation