Clinical markers of post-Chikungunya chronic inflammatory joint disease: A Brazilian cohort.
Carolina Dos Santos LázariMariana Severo RamundoFelipe Ten-CatenClarisse S BressanAna Maria Bispo de FilippisErika Regina ManuliIsabella de MoraesGeovana Maria PereiraMarina Farrel CôrtesDarlan da Silva CandidoAlexandra L GerberAna Paula GuimarãesNuno Rodrigues FariaHelder I NakayaAna Tereza R VasconcelosPatrícia BrasilGláucia Paranhos-BaccalàEster Cerdeira SabinoPublished in: PLoS neglected tropical diseases (2023)
This cohort has provided important insights into the prognostic evaluation of CHIKF. Symptomatic sub-acute disease is a relevant predictor of evolution to chronic arthritis with synovitis, drawing attention to joint pain, edema, multiple articular involvement including small hand and feet joints as risk factors for chronification beyond three months, especially in women. Future studies are needed to accomplish the identification of accurate and early biomarkers of poor clinical prognosis, which would allow better understanding of the disease's evolution and improve patients' management, modifying CHIKF burden on global public health.
Keyphrases
- public health
- ejection fraction
- chronic pain
- newly diagnosed
- zika virus
- oxidative stress
- working memory
- liver failure
- pain management
- polycystic ovary syndrome
- type diabetes
- risk factors
- mass spectrometry
- spinal cord
- patient reported outcomes
- aedes aegypti
- extracorporeal membrane oxygenation
- bioinformatics analysis
- postoperative pain