Synthesis and Biological Evaluation of Novel Anti-leukemia Proteolysis-Targeting Chimeras in Degradating Inosine Monophosphate Dehydrogenase.

Hamidreza SohbatiMohsen AminiSaeed Balalaie

Published in: Iranian journal of pharmaceutical research : IJPR (2022)

The effect of compound 2 in 0.05 μM on IMPDH degradation can be almost prevented by competition with bortezomib as the proteasome inhibitor at 0.1 and 0.5 μM.

Keyphrases

multiple myeloma
acute myeloid leukemia
bone marrow
cancer therapy
newly diagnosed
drug delivery