The anti-parasitic drug miltefosine suppresses activation of human eosinophils and ameliorates allergic inflammation in mice.

Eva GrudenMelanie KienzlAthina TrakakiRudolf SchichoAkos HeinemannEva M SturmGunther Marsche

Published in: British journal of pharmacology (2021)

Our observations suggest a strong modulatory activity of miltefosine in the regulation of eosinophilic inflammation in vitro and in vivo. Our data underline the potential efficacy of miltefosine in the treatment of allergic diseases and other eosinophil-associated disorders and may raise important questions regarding the immunomodulatory effect of miltefosine in patients treated for leishmania infections.

Keyphrases

high fat diet induced
oxidative stress
endothelial cells
allergic rhinitis
signaling pathway
induced pluripotent stem cells
mouse model
emergency department
risk assessment
machine learning
climate change
chronic rhinosinusitis
adverse drug
smoking cessation