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Non-canonical EphA2 activation underpins PTEN-mediated metastatic migration and poor clinical outcome in prostate cancer.

Ashwin SachdevaClaire A HartKyungmin KimThomas TawadrosPedro OliveiraJonathan ShanksMichael D BrownNoel Clarke
Published in: British journal of cancer (2022)
EphA2 MAT-related signalling confers transendothelial invasion. This is associated with a substantially worse prognosis in PTEN-deficient PCa.
Keyphrases
  • prostate cancer
  • pi k akt
  • cell proliferation
  • radical prostatectomy
  • squamous cell carcinoma
  • small cell lung cancer
  • cell migration
  • signaling pathway