Extracellular vesicles derived from DFO-preconditioned canine AT-MSCs reprogram macrophages into M2 phase.
Su-Min ParkJu-Hyun AnJeong Hwa LeeKyung-Bo KimHyung-Kyu ChaeYe-In OhWoo-Jin SongHwa-Young YounPublished in: PloS one (2021)
DFO preconditioning in MSCs activated the HIF-1α/COX-2 signaling pathway; Transferring COX-2 through EVDFO could effectively reprogram macrophage into M2 phase by promoting the phosphorylation of STAT3.